Preventer Plus (Milbemycin oxime & Lufenuron)

  • Preventer Plus Flavor Tabs are given just once a month to prevent heartworm disease and flea populations in dogs and puppies.
  • Controls flea populations and adult hookworms.
  • Removes and controls adult roundworm and whipworm infection in dogs and puppies.

From $21.95






Product Detail: Preventer Plus (Milbemycin oxime & Lufenuron)

Preventer Plus Flavor Tabs

Get the same active ingredients in Sentinel® Flavor Tabs® with Preventer Plus Flavor Tabs that are as effective in preventing heartworm disease and controlling the population of flea eggs and intestinal worms. 

Preventer Plus Flavor Tabs are indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworms) and Trichuris vulpis (whipworm) infections.

Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of adulticide products may be necessary for adequate control of adult fleas.


How Preventer Plus Flavor Tabs work

Preventer Plus Flavor Tabs are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. Preventer Plus is available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. 

Each tablet is formulated to provide a minimum of 0.23 mg/lb (0.5 mg/kg) body weight of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A4 and 20% A3. Milbemycin oxime is classified as a macrocyclic anthelmintic. Lufenuron is a benozylphenylurea derivative and is classified as an insect development inhibitor.


What are the active ingredients of Preventer Plus?

Active ingredients:


How can Preventer Plus be administered to dogs?

Preventer Plus Flavor Tabs are given orally, once a month, at the recommended minimum dosage rate of 0.23 mg/lb (0.5mg/kg) milbemycin oxime and 4.55 mg/lb (10 mg/kg) lufenuron.

Dogs over 100 lbs are provided the appropriate combination of tablets.


To ensure adequate absorption, always administer Preventer Plus Flavor Tabs to dogs immediately after or in conjunction with a normal meal.

Recommended Dosage Schedule for Dogs

Dog Weight         Milbemycin Oxime Per Tablet       Lufenuron Per Tablet                       

2-10 lbs.                            2.3 mg                                        46.0 mg

11-25 lbs.                          5.75 mg                                      115 mg

26-50 lbs.                         11.5 mg                                       230mg

51-100 lbs.                       23.0 mg                                       460 mg


Is there an easy way in giving Preventer Plus to dogs?

Preventer Plus Flavor Tabs are palatable and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet. 

Administer Preventer Plus Flavor Tabs to dogs immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed.

Preventer Plus Flavor Tabs must be administered monthly, preferably on the same date each month. Treatment may begin at any time of year. 

In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of mosquito and flea season. In areas with year-round infestations, treatment should continue through the entire year without interruption.

If a dose is missed and a 30-day interval between dosing is exceeded, administer Preventer Plus immediately and resume the monthly dosing schedule. If Preventer Plus Flavor Tabs replace daily diethylcarbamazine (DEC) for heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.


What are the precautions when using Preventer Plus Flavor Tabs?

Do not use in puppies less than four weeks of age and less than two pounds of body weight. Prior to initiation of the Preventer Plus Flavor Tabs treatment program, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with Preventer Plus Flavor Tabs. 

Preventer Plus Flavor Tabs immediately break the flea life cycle by inhibiting egg development. However, pre-existing flea populations may continue to develop and emerge after treatment has begun. Based on the results of clinical studies, this emergence generally occurs during the first 30-60 days. Therefore, noticeable control may not be observed until several weeks after dosing when a pre-existing infestation is present.

Ratings & Reviews

Based on 24 Review(s)

Average Rating


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Most Recent Reviews
Written by David E. Purswell
Sep 07, 2021

This product is easy to give my dog, and Petshed has been very easy to place orders and receive too.

Happily gobble this up!
Written by Sassy
Jun 11, 2021

My girls, Sunflower and Daisy, chomp this little pill up. This is all they've had since they were rescued. We don't know the difference between the fancy kind and the affordable kind. Never seen a flea, tick, or had any issues. Thanks so much, Pet Shed!

Works just as well as Sentinel
Written by Jack Brown
Apr 01, 2021

I've been buying Sentinel for years. Found this generic. It works just as well and is much cheaper. Happy puppy and Dad!

It works!
Written by Aurora Pirellu
Nov 13, 2017

This product works! ya'll must give it a try, you'll save a lot and you'll definitely get your babies protected from harm. You're like hitting two birds in one stone! Perfect!

Never seen a flea on my outside dogs!
Written by khou
Aug 17, 2017

I have two labs that stay outside. With this pill I have had only 1 tick in 6 months and have never seen a flea on my girls! Very much worth it!

Heartworm and fleas?
Written by Julie
Aug 08, 2017

These parasites are now afraid of this medication, they should be!! How great is our love to our Pets so thank you Pet Shed for providing real great meds!

Great Product
Written by Misty
Jun 08, 2017

Liz is a yorkshire about 9lbs did love the product. I can't afford the name brand sentinel anymore as I have a limited income. being old is somehow hard but the beauty of life won't stop just because I am old. I'm doing my responsibility for my baby Liz in the best way I can. I'm so emotional right now but I'd like to thank Pet Shed for this opportunity. I've been a customer for years and I trust pet Shed. Thanks a lot!

Written by Linda Author
Jun 07, 2017

I like the notion of saving money but getting the most from what you spent. This pretty works just like the one made by Novartis. It targets 3 in one tab!!

Written by Thomas Smith
Jun 02, 2017

So easy to purchase! Very affordable and it works! Thank you!

super happy!
Written by Tom S.
Jun 02, 2017

No heart worm, no fleas! super happy!