Generic Heartgard Plus (Ivermectin & Pyrantel)
  • Generic Heartgard Plus (Ivermectin & Pyrantel)

Generic Heartgard Plus (Ivermectin & Pyrantel)

  • For use in dogs to prevent canine heartworm disease
  • Eliminates the tissue stage of heartworm larvae (Dirofilaria immitis) for a month after infection
  • For the treatment and control of ascarids and hookworms
  • Safe in puppies of 6 weeks of age and older
  • Provides month long protection
  • Available as easy-chew tablets


From $15.95






Product Detail: Generic Heartgard Plus (Ivermectin & Pyrantel)


For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms(Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).

HeartShade Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:
Dog Weight Tablets Ivermectin Pyrantel
(Kg) Per Month Content Content
Upto 11 1 68 mcg 57 mg
12 to 22 1 136 mcg 114 mg
23 to 45 1 272 mcg 227 mg

HeartShade Plus is recommended for dogs 6 weeks of age and older.
For dogs over 100 lb (45kg) use the appropriate combination of these tablets.

Remove only one tablet at a time from the foil-backed blister card. Return the card with the remaining tablets to its box to protect the product from light. Because most dogs find HeartShade Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. Tablets may be broken into pieces and fed to dogs that normally swallow treats whole.
Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the doses has been lost, re-dosing is recommended.
HeartShade Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HeartShade Plus must be given within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HeartShade Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
Monthly treatment with HeartShade Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

HeartShade Plus (ivermectin/pyrantel) Tablets, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage.
HeartShade Plus Tablets are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense).

All dogs should be tested for existing heartworm infection before starting treatment with HeartShade Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HeartShade Plus.
While some microfilariae may be killed by the ivermectin in HeartShade Plus at the recommended dose level, HeartShade Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in reported clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
Store between 68 F-77 F (20-25C). Excursions between 59F-86F (15-30C) are permitted. Protect product from light.

In reported clinical field trials with HeartShade Plus, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of HeartShade Plus: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

Reported studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. HeartShade Plus demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies.
Results of these trials and reported bioequivalence studies support the safety of HeartShade Plus products in dogs, including Collies, when used as recommended.
HeartShade Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with HeartShade Plus in a heartworm disease preventing program.
In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.

How Supplied: HeartShade Plus is available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength comes in convenient cartons of 6 Chewable Tablets.

Ratings & Reviews

Based on 189 Review(s)

Average Rating


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Most Recent Reviews

This stuff is the real deal.
Written by SpooGuy
Aug 01, 2021

My folks, and I have been using this medicine on our dogs for years. I was quite surprised when I found out they were also buying from PetShed. We are a western ran hung family and have been around livestock for generations. Previously, I was dosing swine/bovine ivermectin to our dogs to save a buck, but this medicine alleviates the dangerous micro-dosing of large-animal meds for dogs. For those of you having trouble, open your dog?s mouth, put the tablet on the back of the tongue, and push it back as far as you can with your index finger. It?s like using a balling gun on livestock!

works good
Written by gayle
Apr 07, 2021

I have been ordering this for my dogs for many years never a positive test on them. So were ever it comes from still working good.

Great Product
Written by Seajay128
Nov 02, 2020

The best for less! I have 4 dogs and this heartworm prevention I have been using for years and my fur kids have never tested positive for heart worm. I recommend it A++

You asked where Vetbiochem "generics" are made?
Written by John
Sep 27, 2020

The Vetbiochem Group has operations in many countries with its head-quarters based in Moscow, Russia. Vetbiochem India Pvt. Ltd is established in 2007 in Pune, India which caters to the Veterinary demand of International clients by manufacturing products in India.

Using for years
Written by Lori
Aug 02, 2020

A friend of mine told me about Pet Shed about 16 years ago when we rescued our boy, Gordon. He never, ever had an issue. Now, my boy is gone, but we rescued Lilith. She has been on this for 3 years since we lost Gordon. I trust this product to do what it says.

My dogs approve
Written by Kris P
Jul 17, 2020

I was nervous my picky dogs wouldn't eat these like they do with the regular Heartgard. No problem at all though. They take them and eat with no issues. I love that this is the same active ingredients and a lot lower price.

Written by Linda
Jul 20, 2019

Does anyone know where these pills are manufactured?

Heart Shade Plus
Written by Benji
Feb 22, 2019

So far so good.. they seem to be very ok with this brand.. I know I'm very Happy, because they are healthy.. thanks, so much.. Great price...

Best Generic Available
Written by eb102
Aug 16, 2017

I have been using this product for over 15 years. Never have I had a positive heart worm test on my labradors. I will continue to use the product, as for finicky eaters, if peanut butter won't do the trick, it's your dime. I will use my savings on other things.

Written by Linda Author
Jun 07, 2017

This is effective!! and I highly recommend this product it works just like the heartgard plus. The great about this is the money you can save. Name Brand of the Heartgard for small dogs 6pack is $27.95 wherein the generic version is only $13.95 that a $14 savings. I can buy another 6 pack to have it 12 months supply, but i won't do that. I'll just buy a 12 month supply for a small dog for only $25.95 instead of buying two 6 pack that sums to $27.90. Bottomline, this can save you alot!