Frontline Plus

Frontline Plus features

  • Kills fleas for at least one month
  • Controls and treats Flea Allergy Dermatitis
  • Kills all known ticks for at least one month
  • Water-resistant
  • Easy to administer spot-on application
  • Each tube contains Fipronil & S-Methoprene

Select the generic alternative and save even more $$$

Generic Frontline
Generic Frontline
Generic Frontline
Generic Frontline
Generic Frontline

From $33.95


Style Number: MSD14-CONFIG

Product Detail: Frontline Plus

Information about Frontline Plus

Frontline Plus provides protection against fleas and ticks, and contains a special ingredient to kill flea eggs and larvae. By stopping the development of new fleas, Frontline Plus provides the most complete flea and tick protection available. Frontline Plus kills 100% of fleas and ticks within 48 hours, including many ticks that transmit dangerous diseases that can affect other pets and humans.

Frontline Plus Flea Control has been formulated for use on puppies and kittens from eight weeks of age and is safe for use on pregnant and lactating animals. It is a water-resistant flea medication, so it continues to kill fleas even after shampooing, swimming, rain or exposure to sunlight.

Learn More About Frontline Plus

Product Information Schedule

N.B. Pet Shed sells the Australian versions of the products listed below.
Metric conversion: 1 kg = 2.2 lbs

  Dosage Active Ingredients For cats
Frontline Plus for Cats (Green Box)      
Australian Version, NRA Approval No. 54524 0.5 mL 100 g/L Fipronil & 120 g/L (S)-Methoprene 8 weeks or older
USA Version, EPA Reg. No. 65331-4 0.017 fl oz (0.5 ml) 9.8% Fipronil & 11.8% (S)-Methoprene (by weight) 8 weeks or older
  Dosage Concentration For dogs weighing
Frontline Plus for Dogs (Orange Box)      
Australian Version, NRA Approval No. 54523 0.67 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene Up to 10kg
USA Version, EPA Reg. No. 65331-5 0.023 fl oz (0.67 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) Up to 22 lbs
Frontline Plus for Dogs (Blue Box)      
Australian Version, NRA Approval No. 54523 1.34 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene 10-20 kg
USA Version, EPA Reg. No. 65331-5 0.045 fl oz (1.34 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) 23-44 lbs
Frontline Plus for Dogs (Purple Box)      
Australian Version, NRA Approval No. 54523 2.68 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene 20-40 kg
USA Version, EPA Reg. No. 65331-5 0.091 fl oz (2.68 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) 45-88 lbs
Frontline Plus for Dogs (Red Box)      
Australian Version, NRA Approval No. 54523 4.02 mL 100 g/L Fipronil & 90 g/L (S)-Methoprene 40-60 kg
USA Version, EPA Reg. No. 65331-5 0.136 fl oz (4.02 mL) 9.8% Fipronil & 8.8% (S)-Methoprene (by weight) 89-132 lbs

Frontline Plus has been approved for sale in Australia by the APVMA. The US equivalent of this product has been approved for sale by the EPA.

Both the Australian and US products contain the same active ingredients, Fipronil & (S)-Methoprene.

However, the products sold by Pet Shed are sold in Australian packaging which has not been approved for sale in the US. As a consequence, the Australian packaging does not have EPA approval and the sale and purchase of products in the Australian packaging may be illegal in the US.

If swallowed call a poison control center or doctor immediately for treatment advice. For hazards to domestic animals the 24 hour assistance line within the U.S.A. is 1-800-660-1842.

The Product Information Schedule above indicates some of the material differences between the Australian and U.S.A. versions.

Ratings & Reviews

Based on 373 Review(s)

Average Rating


Ratings Overview











Most Recent Reviews

Pet Shed Is The Best!
Written by Heartland U.S.A.
Sep 03, 2015

After years of spending so much money through our vet for Frontline Plus I was surprised to find out that I can order it from Pet Shed for a LOT less and WITHOUT a prescription from my vet. It arrived quickly and is the same high quality ingredients we love, just for a LOT less. Thanks!!!

Great protection for your pets!
Written by Nancy
Aug 17, 2015

I won't use anything else for my dogs. Even my vet recommends Frontline Plus. My dogs have never had problems with fleas or ticks with the use of Frontline Plus. Such a great product.

Written by Bobbie
Aug 17, 2015

I have used Frontline Plus for fleas and ticks for years, and have always been pleased with it's performance. But as a retiree was concerned about cost. I found Pet Shed and their great pricing. My biggest concern was that these might be 'seconds' or expired meds. I found much to my appreciation that these are first quality meds with normal expiration dates. thank you Pet Shed!!

Great Product!
Written by Robert
Aug 09, 2015

If you are unsure of which flea and tic product to use, try Frontline Plus. You and your dog won't be disappointed. We have tried other products, but none work as well as Frontline. Well worth the premium price. Follow directions and you won't find your dog scratching or bothered by pests. I've noticed over the years that Pet Shed generally has the best price too. I do wish they offered more free shipping opportunities though :)

You can count on this one
Written by Bill Mosca
Aug 02, 2015

We've tried other brands, but my dog and cat just hate them. Frontline Plus doesn't seem to bother them. And it's very effective. Once we accidentally skipped about 2 months, thinking the other had applied the dose. My dog ended up with a bad case of fleas. After applying Frontline Plus all the fleas were gone in less than 2 days. And none were ever spotted again. And Pet Shed has the best prices and reliable shipping I could find, bar none.

Best on the market
Written by Linc 'n Pete
Jul 29, 2015

We tried every flea product sold on the shelves at Petsmart when we first introduced an ASPCA dog into a house with two flea-less house cats. The dog was flea-ridden and absolutely nothing worked for months--until FRONTLINE. Do not be fooled by any other product! This is the only stuff that truly performs as advertised, and really works. We haven't had a flea or tick (no live ones, anyway) in years.

Written by Karen
Jul 29, 2015

Frontline does an awsome job of keeping my pets safe and bug free. I've tried a lot of brands and Frontline is definitely #1. I hate the packaging though. It's hard to open and I get treated for fleas about everytime I open one. I wish there go to more user friendly packaging.

Used Frontline for my dog for 10 years in Texas!
Written by sbparker
Jul 22, 2015

There have been no fleas or ticks on my dog in Houston, Texas in the past 10 years because I have used Frontline! I found it much less expensive on the Pet Shed website than in the United States and it is so convenient to order. It is delivered in about a week from PetShed to the USA.

Frontline Plus
Written by Jeasta
Jun 30, 2015

I've been buying Frontline Plus for several years from and am pleased with the product, expiration dates have always been great, and it ships pretty fast as well.

Frontline Plus/Pet Shed Service
Written by Yolanda
Jun 06, 2015

Pet Shed is where I purchase Frontline Plus (6 pack) for my 3 small dogs. I need to purchase Frontline to keep the fleas off them. Frontline works for them. From what I have been able to research Pet Shed is the economical way to go to purchase this product. All the other stores and vet offices around my area offer Frontline but their prices are crazy expensive. Thank you Pet Shed for providing this product at a decent cost.