Product Uses
Atopica is indicated for the control of atopic dermatitis (atopy) in dogs.
Product Contains
Cyclosporine, USP modified
Dosage and Administration
The initial daily dose of Atopica is 5 mg/kg/day (3.3-6.7 mg/kg/day) as a
single daily dose for 30 days. Following the initial daily treatment
period, the dose of Atopica may be tapered by decreasing the frequency of
dosing to every other day or twice a week, to maintain the desired
therapeutic effect.
Atopica should be given at least one hour before
or two hours after a meal. If a dose is missed, the next dose should be
administered (without doubling it) as soon as possible, but dosing should
be no more frequent than once daily.
Warnings, Side Effects and Drug Interactions
Atopica is contraindicated for use in dogs with a history of
malignant tumors.
Gastrointestinal problems and gum overgrowth may
occur at the initial recommended dose.
Atopica should be used with
caution concurrently with medications which affect the metabolism of the
drug in the liver as this may lead to increased plasma levels of
cyclosporine and an increased risk of toxic effects.
The safety and
effectiveness of Atopica has not been established in dogs less than 6
months of age or less than 4 lbs body weight. Atopica is not for use in
breeding dogs, pregnant or lactating females.
There have been reports
of convulsions in human patients receiving cyclosporine, particularly in
combination with a high dose of methylprednisolone (a
corticosteriod).
Killed vaccines are recommended for dogs receiving
Atopica because the impact of the drug on the immune response to modified
live vaccines is unknown.
Diarrhea, vomiting, ear infections, urinary
tract infections, anorexia, gum overgrowth, enlarged lymph nodes,
depression, excessive drinking and urinating, soft stools, seizures,
itching, red skin, nausea, regurgitation, constipation and flatulence
have been seen in association with cyclosporine therapy. Of these,
vomiting and diarrhea are the most common adverse reactions. In overseas
countries, acute collapse, pale mucous membranes and delayed capillary
refill time, weakness, and diarrhea with blood have also been noted.
Storage
Atopica should be stored and dispensed in the original unit-dose container at controlled room temperature between 59 and 77°F (15-25°C).
Manufacturer
Novartis Animal Health
Federal law restricts this drug to use by or on the order of a licensed
veterinarian.
Atopica
