Product Uses
Zubrin Tablets are indicated for the control of pain and inflammation associated with osteoarthritis in dogs.
Product Contains
tepoxalin
Dosage and Administration
Administer 10 mg/kg (4.5 mg/lb) or 20 mg/kg (9.1 mg/lb) on the initial day of treatment, followed by a daily maintenance dose of 10 mg/kg. When administered orally, the rapidly dissolving tablets disintegrate in the mouth within seconds after placement on the tongue. The mouth should be kept closed for a sufficient amount of time (~4 seconds) to ensure tablet dispersion. Zubrin Tablets should be administered either with food or within 1 to 2 hours after feeding for best effect.
Warnings, Side Effects and Drug Interactions
Note that due to tablet sizes, dogs weighing less than 3 kg (6.6 lbs) cannot be accurately dosed. Zubrin Tablets should not be used in dogs exhibiting previous hypersensitivity to tepoxalin. The safety of Zubrin Tablets has not been investigated in breeding, pregnant, or lactating dogs, or in dogs younger than 6 months of age.
As a class, NSAIDs, such as tepoxalin, can be associated with gastrointestinal, kidney and liver toxicity. Animals at greatest risk are those with kidney, heart or liver disease, or those which are dehydrated. The most commonly reported reactions are vomiting and diarrhea, occasionally bloody.
Additional adverse reactions seen in association with Zubrin use include: decreased appetite, inco-ordination, lethargy, flatulence, trembling, incontinence and hair loss. In rare situations, death has been reported. It is not recommended to give Zubrin in conjunction with any drugs which could exacerbate toxicity, such as corticosteroids or other NSAIDs or any drugs known to be toxic to kidneys. Zubrin is not recommended for use in dogs with bleeding disorders. Care should be taken if administering with other drugs which are highly protein bound or metabolized through the liver, as this may increase the availability of the drug and cause adverse effects. If any signs of toxicity occur, such as a loss of appetite, vomiting, fecal abnormalities, anemia, jaundice, or lethargy, stop treatment and consult your veterinarian for treatment advice.
Storage
Store between 2° and 30°C (36° and 86°F).
Manufacturer
Schering-Plough Animal Health
Registration Status
NADA #141-193, Approved by FDA
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Zubrin
