Centrine

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Product Uses

Centrine is a potent antispasmodic agent for smooth muscle. Centrine is indicated in the treatment of acute abdominal organ spasm, or inflammation and associated nausea, vomiting and/or diarrhea. Centrine causes a reduction in secretions in the stomach, a decrease in stomach acidity and a marked decrease in gastro-intestinal motility.

Product Contains

Aminopentamide hydrogen sulfate

Dosage and Administration

Centrine tablets may be administered alone, or following injection, at a dose of 0.1mg for animals 10lb or less, up to 0.5mg for animals of greater than 100lb. If the desired effect is not obtained, the dosage may be gradually increased.

Warnings, Side Effects and Drug Interactions

Dryness of the mouth is the most commonly reported side effect of Centrine use. Blurring of vision may occur and dryness of the eyes may occur if larger (greater than therapeutic) doses are used. It should not be used in animals with glaucoma because of the occurrence of enlarged pupils.
Centrine should be used cautiously, if at all, in obstruction of the stomach because of its action in delaying gastric emptying. These effects frequently decrease with continued administration of the drug. Disturbances in urination are infrequent and vary from slightly hesitancy in initiating urination to complete inability to urinate; the latter is an indication for discontinuing the drug. After a day or two, it may be resumed at a lower dosage level.