Product Uses
Clomipramine is a tricyclic antidepressant human medication, occasionally employed by veterinarians to treat anxiety-related disorders in dogs and cats. This product is not licensed for use in animals. It is similar to the product Clomicalm, which is licensed for use in animals.
Product Contains
Clomipramine
Dosage and Administration
The recommended daily dose of the animal-registered product tablets is 2 to 4 mg/kg/day (0.9-1.8 mg/lb/day), administered as a single daily dose or divided twice daily based on patient response and/or tolerance of the side effects. To reduce the incidence of vomiting that may be experienced by some dogs, it may be given with a small amount of food. Once the desired effect is achieved and the appropriate behavioral modification has been successfully implemented, the dose may be reduced to maintain the desired effect or discontinued altogether. Continued behavioral modification is recommended to prevent recurrence of the clinical signs.
Warnings, Side Effects and Drug Interactions
The animal-registered product should not be given in combination, or within 14 days before or after treatment with a monoamine oxidase inhibitor (e.g. selegiline, amitraz) and are contraindicated for use in dogs with a history of seizures or in conjunction with drugs which lower the seizure threshold. Caution is advised in using clomipramine with phenobarbital, anticholinergic or sympathomimetic drugs or with other drugs with nervous effects. Prior to elective surgery with general anesthetics, clomipramine should be discontinued for as long as possible. Clomipramine should be used with caution in dogs with cardiovascular disease, increased pressure within the eye or a history of glaucoma, urinary retention or reduced gut motility. Because clomipramine is principally metabolized in the liver, caution is advised in using this medication in the presence of preexisting liver disease.
Adverse reactions seen in post-approval adverse drug experience reporting for the animal-registered product include: lethargy/depression, anorexia, elevation in liver enzymes, vomiting and diarrhea. Liver and bile duct disease has occurred, especially in the presence of pre-existing conditions or with concurrent administration of drugs metabolized via the liver. Additionally, in an overdose situation, the following signs have been reported: ataxia, enlarged pupils, elevated heart rate and vocalization. In pre-release trials, aggression (growling) was seen in a small proportion of dogs treated with the animal-registered product.
Safety studies to determine the effects of the animal-registered product in pregnant or lactating female dogs have not been conducted, but this should not be used in breeding males.
Should any signs of intolerance to clomipramine occur in your pet, discontinue therapy and contact your veterinarian for advice.
Storage
Store at a controlled room temperature between 59-86°F (15-30°C).
Manufacturer
Various generic manufacturers
This is a human product, which is not licensed with the FDA for use in animals. The use of this product by your veterinarian is at their discretion - your veterinarian is responsible for determining the appropriate dose rate and managing any side effects which may occur in association with this product.
Clomipramine (Generic Alternative to Clomicalm)
