Product Detail: Generic Frontline Top Spot
This fiprofort contains same active ingredients as Frontline from Merial.
Each pipette contains:
Fipronil 9.7% w/v
Fiprofort for Cat and Dog provides convenient and effective flea and tick control. It provides protection upto 6 months against fleas and 3 months against ticks depending on the level of environmental challenge.
FIPROFORT for Cat provides convenient and effective flea and tick control for cats and kittens 8 weeks or older. It provides protection up to 15 weeks against fleas depending on the level of environmental challenge.
Fiprofort for Dog provides convenient and effective flea and tick control for dogs and puppies over 10 weeks of age. It provides protection upto 6 months against fleas and 3 months against ticks depending on the level of environmental challenge.
Fipronil is an insecticide acaricide belonging to the family phenylpyrazole. It works by inhibiting the GABA complex, thus blocking the transfer of chloride ions through the membrane at the pre and post-synaptic binding in the chloride channel. It thus causes uncontrolled activity of the central nervous system and death of insects and mites.
Reported studies showed that absolute bioavailability of fipronil was 9.5 %. The mean maximum concentration (Cmax) was found to be 19 max ng/ml in plasma found after 5 days (Tmax). Plasma concentrations were below 1 ng/ml (limit of quantification) by approximately 33 days max following topical administration.
Fipronil’s major metabolite on the haircoat of the dog and in the blood stream is the sulfone derivative. Fipronilsulfone is produced on the haircoat (mean concentrations < 16 % of fipronil during the first month after treatment).
The plasma fipronil concentrations slowly reached a peak average about 101 hours and decreasing slowly (half-life) by approximately 154 hours, the highest values are observed in males. The concentration of fipronil and fipronilsulfone in peeling decreases with time, but are detectable at least 60 days after application in dogs.
Parasites are killed mainly by contact and not by systemic exposure.
Cure and prevention of infestations by fleas, ticks and biting lice. The duration of protection against new infestation is two months for fleas and one month for ticks. The drug can be incorporated into a treatment of Flea Allergy Dermatitis.
DOSAGE AND ADMINISTRATION:
Weight (kg) Weight (pounds) Dose
Dogs up to 10 kg Dogs up to 22 lbs 0.67 ml (0.023 fl oz) / Pipette
Dogs over 10 kg upto 20 kg Dogs over 22 lbs upto 44 lbs 1.34 ml (0.045 fl oz) / Pipette
Dogs over 20 kg upto 40 kg Dogs over 44 lbs upto 88 lbs 2.68 ml (0.091 fl oz) / Pipette
Dogs over 40 kg upto 60 kg Dogs over 88 lbs upto 132 lbs 4.02 ml (0.136 fl oz) / Pipette
For dogs over 60 kg For Dogs over 132 lbs Two pipettes of 2.68 ml (0.091fl oz)
DISPOSAL: Securely wrap pipettes in several layers of newspaper and discard in trash.
STORAGE: Store below 30°C in dark place. Protect from heat.